EU-ToxRisk is an Integrated European ‘Flagship’ Programme Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st century. The vision of this project is to drive the required paradigm shift in toxicological testing away from ‘black box’ animal testing towards a toxicological assessment based on human cell responses and a comprehensive mechanistic understanding of cause-consequence ...
Re-engineering pharmaceutical research, a scientist’s opinion Interview with Aroon Hingorani, Professor of Genetic Epidemiology at University College London. Could you speculate what you think are the biggest causes of drug failure? It is well recognised that the number one cause for drug failure is a lack of efficacy of the drug in the intended indication, ...
Re-engineering pharmaceutical research, a scientist’s opinion Interview with Dr Denis Lacombe, Director General of the European Organisation for Research and Treatment of Cancer (EORTC). Can you tell me a bit about the European Organisation for Research and Treatment of Cancer (EORTC)? We are a non-governmental, not-for-profit organisation established for 60 years, focusing on survival and ...
A so-called ‘productivity crisis’ has been ascribed to the pharmaceutical research and development industry. Despite increases in investment and funding, this has not corresponded to increases in the approval of novel drugs. Why do so many drugs fail to receive approval, and what other means should we be focusing on for the benefit of patients?
Re-engineering pharmaceutical research, a scientist’s opinion Interview with Dr Síle Lane, head of international campaigns and policy at Sense About Science. Undisclosed clinical trial results are unfortunately common - how does this impact progression in research and treatment? When results from clinical trials aren’t published it means the same research can get repeated unnecessarily. This ...
onJanuary 15, 2020
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