Patients with severe COVID-19 pneumonia often need to be mechanically intubated and have an increased mortality risk. Tocilizumab, a drug used against the cytokine storm underlying this clinical condition, has shown positive effects in clinical trials.
Although according to the World Health Organization the novel coronavirus is primarily transmitted between people through respiratory droplets and contact routes, some scientists suggest we should also consider the possibility of aerosol transmission. As the pandemic continues to unfold, research and discussions are ongoing to determine how best to tackle it. Two leading experts offer their opinions, alongside an exploration into some of the vital research being conducted.
In 1959, The Principles of Humane Experimental Technique was published by Russell and Burch, introducing the 3Rs concept (replacement, reduction, and refinement) regarding animal use in the scientific community. Just over 60 years later, it is timely to review progress to date and the future outlook regarding alternative approaches to animal testing.